Impact of a Novel Hydrogel with Injectable Platelet-Rich Fibrin in Diabetic Wound Healing

Diabetic wounds are serious complications caused by diabetes mellitus (DM), which further exacerbated angiogenesis disorders and prolonged inflammation. Injectable platelet-rich fibrin (i-PRF) is rich in growth factors (GFs) has been used for the repair regeneration of diabetic wounds; however, direct application i-PRF certain disadvantages, including instability bioactive molecules. Sericin hydrogel, fabricated silkworm-derived sericin, a biocompatible material that anti-inflammatory healing-promoting properties. Therefore, this study, we developed novel hydrogel (named sericin/i-PRF hydrogel) using simple one-step activation method. The vitro studies showed rapid injectability allows it to adapt irregular shape wounds. Additionally, sericin could prolong release i-PRF-derived GFs hydrogel. Furthermore, effectively repaired wounds, promoted angiogenesis, reduced inflammation levels nude mice. These results demonstrate promising agent wound healing.